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Cat. No. M10569
Bombesin Structure
Size Price Availability Quantity
5mg USD 224  USD224 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Bombesin is a tetradecapeptide, which plays an important role in the release of gastrin and the activation of G-protein receptors. Bombesin is found to have stimulatory effects upon gastric and pancreatic secretions, release of gastrointestinal hormones, gallbladder contraction and bronchoconstriction. It is present in amphibian gastric endocrine cells, avian proventriculus endocrine cells and avian brain. In mammals it is present mainly in nerve cells and fibers. The only mammalian endocrine cell shown to date to have bombesin is the P-cell in fetal lung. Bombesin is shown to be a potent mitogen for Swiss 3T3 cells. In the presence of a low concentration (3.5%) of serum, bombesin stimulates 3T3 cell proliferation. In serum-free medium, bombesin induces DNA synthesis in the absence of any other added growth factor with IC50 of 1 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 1619.85
Formula C71H110N24O18S
CAS Number 31362-50-2
Purity >99%
Solubility 0.05M acetic acid 20 mg/mL
Water 1 mg/mL
Storage -20°C, protect from light, sealed

[1] Nieves Gonzalez, et al. Curr Opin Endocrinol Diabetes Obes. Bombesin-related peptides and their receptors: recent advances in their role in physiology and disease states

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Abmole Inhibitor Catalog 2017

Keywords: Bombesin supplier, inhibitors

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