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Bombesin is a tetradecapeptide, which plays an important role in the release of gastrin and the activation of G-protein receptors. Bombesin is found to have stimulatory effects upon gastric and pancreatic secretions, release of gastrointestinal hormones, gallbladder contraction and bronchoconstriction. It is present in amphibian gastric endocrine cells, avian proventriculus endocrine cells and avian brain. In mammals it is present mainly in nerve cells and fibers. The only mammalian endocrine cell shown to date to have bombesin is the P-cell in fetal lung. Bombesin is shown to be a potent mitogen for Swiss 3T3 cells. In the presence of a low concentration (3.5%) of serum, bombesin stimulates 3T3 cell proliferation. In serum-free medium, bombesin induces DNA synthesis in the absence of any other added growth factor with IC50 of 1 nM.
| Molecular Weight | 1619.85 |
| Formula | C71H110N24O18S |
| CAS Number | 31362-50-2 |
| Solubility (25°C) | 0.05M acetic acid 20 mg/mL Water 1 mg/mL |
| Storage | -20°C, protect from light, sealed |
| Related Bombesin Receptor Products |
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| RC-3095 TFA
RC-3095 TFA is a selective bombesin/gastrin releasing peptide receptor (GRPR) antagonist. |
| Litorin
Litorin, an amphibian bombesin peptide derivative, is an bombesin receptor agonist. |
| (D-Phe6, Leu-NHEt13, des-Met14)-Bombesin (6-14)
(D-Phe6,Leu-NHEt13,des-Met14)-Bombesin (6-14) is a bombesin (BBN) antagonist and can be used for the research of cancer. |
| BIM 23042
BIM 23042, a certain somatostatin (SS) octapeptide analogue, is a selective neuropeptide neuromedin B receptor (NMB-R, BB1) antagonist. |
| BIM-26226
BIM-26226, gastrin-releasing peptide, is a potent and selective antagonist of bombesin receptor. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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