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BMS-986187

Cat. No. M21375

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BMS-986187 Structure

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Quality Control & Documentation
Biological Activity

BMS-986187 is a δ-opioid receptor selective orthosteric modulator (PAM) with an EC50 of 0.03 μM and a pKB of 6.02 (~1 μM). bms-986187 has no observable PAM activity at the μ receptor (EC50=3 μM).

Chemical Information
Molecular Weight 470.60
Formula C31 H34 O4
CAS Number 684238-37-7
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jesse J DiCello, et al. Am J Physiol Gastrointest Liver Physiol. Positive allosteric modulation of endogenous delta opioid receptor signaling in the enteric nervous system is a potential treatment for gastrointestinal motility disorders

[2] M Alexander Stanczyk, et al. Br J Pharmacol. The δ-opioid receptor positive allosteric modulator BMS 986187 is a G-protein-biased allosteric agonist

[3] Kathryn E Livingston, et al. Mol Pharmacol. Pharmacologic Evidence for a Putative Conserved Allosteric Site on Opioid Receptors

[4] Yi Shang, et al. ACS Chem Biol. Proposed Mode of Binding and Action of Positive Allosteric Modulators at Opioid Receptors

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Keywords: BMS-986187 supplier, Opioid Receptor, inhibitors, activators

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