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BMS-309403 sodium is a potent, orally active, and selective adipocyte fatty acid binding protein (also known as FABP4, aP2) inhibitor, with Kis of <2, 250, and 350 nM for FABP4, FABP3, and FABP5, respectively. BMS-309403 sodium interacts with the fatty-acid-binding pocket within the interior of the protein and competitively inhibits the binding of endogenous fatty acids. BMS-309403 sodium improves endothelial function in apolipoprotein E-deficient mice and in cultured human endothelial cells.
| Molecular Weight | 496.53 |
| CAS Number | 300657-03-8 (free base) |
| Solubility (25°C) | Water 90 mg/mL DMSO 50 mg/mL |
| Storage | 2-8°C, dry, sealed |
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