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Cat. No. M29698

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BMS-262084  Structure
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Biological Activity

BMS-262084 is a potent, selective and irreversible inhibitor of factor XIa, with an IC50 of 2.8 nM against human factor XIa. BMS-262084 also inhibits human tryptase (IC50=5 nM). BMS-262084 exhibits antithrombotic effects.

Chemical Information
Molecular Weight 425.48
Formula C18H31N7O5
CAS Number 253174-92-4
Form Solid
Solubility (25°C) DMSO 50 mg/mL (ultrasonic and warming and heat to 60°C)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month

[1] Pancras C Wong, et al. J Thromb Thrombolysis. A small-molecule factor XIa inhibitor produces antithrombotic efficacy with minimal bleeding time prolongation in rabbits

[2] Antonio Gómez-Outes, et al. Ther Adv Cardiovasc Dis. New parenteral anticoagulants in development

[3] William A Schumacher, et al. Eur J Pharmacol. Antithrombotic and hemostatic effects of a small molecule factor XIa inhibitor in rats

[4] Amrita V Kamath, et al. J Pharm Sci. Multiple pathways are involved in the oral absorption of BMS-262084, a tryptase inhibitor, in rats: role of paracellular transport, binding to trypsin, and P-glycoprotein efflux

[5] Xinhua Qian, et al. J Org Chem. A stereoselective synthesis of BMS-262084, an azetidinone-based tryptase inhibitor

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Abmole Inhibitor Catalog

Keywords: BMS-262084  supplier, Factor Xa, inhibitors, activators

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