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Fisogatinib (BLU-554)

Cat. No. M5237
Fisogatinib (BLU-554) Structure
Synonym:

BLU554; Fisogatinib

Size Price Availability Quantity
5mg USD 145  USD145 In stock
10mg USD 240  USD240 In stock
50mg USD 720  USD720 In stock
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Quality Control
Biological Activity

In vitro´╝ÜFisogatinib (BLU-554) exploits a unique interaction with FGFR4 to confer potency and selectivity.

In vivo: Fisogatinib (BLU-554) is well tolerated in these tumor models. Administration of Fisogatinib (BLU-554) induces tumor regression in liver cancer models.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 503.38
Formula C24H24Cl2N4O4
CAS Number 1707289-21-1
Purity 98.96%
Solubility 100 mg/mL in DMSO
Storage at -20°C
References

[1] Hagel M, et al. Cancer Discov. First Selective Small Molecule Inhibitor of FGFR4 for the Treatment of Hepatocellular Carcinomas with an Activated FGFR4 Signaling Pathway.

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Keywords: Fisogatinib (BLU-554), BLU554; Fisogatinib supplier, FGFR, inhibitors

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