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Fisogatinib (BLU-554) is a potent, highly-selective, oral FGFR4 inhibitor with an IC50 value of 5 nM. The IC50s for FGFR1-3 is 624-2203 nM.
In vitro：Fisogatinib (BLU-554) exploits a unique interaction with FGFR4 to confer potency and selectivity.
In vivo: Fisogatinib (BLU-554) is well tolerated in these tumor models. Administration of Fisogatinib (BLU-554) induces tumor regression in liver cancer models.
| Molecular Weight | 503.38 |
| Formula | C24H24Cl2N4O4 |
| CAS Number | 1707289-21-1 |
| Solubility (25°C) | 100 mg/mL in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related FGFR Products |
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| Aprutumab ixadotin
Aprutumab ixadotin is an antibody drug coupling (ADC) with a non-cleavable linker that targets FGFR2. |
| Gunagratinib
Gunagratinib is an orally active, potent, selective, and irreversible fibroblast growth factor receptor (pan-FGFR) inhibitor for use in cancer research. |
| SAR-442501
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