Free shipping on all orders over $ 500

BLT-1

Cat. No. M8217
BLT-1 Structure
Synonym:

Block lipid transport-1

Size Price Availability Quantity
5mg USD 99  USD110 In stock
10mg USD 162  USD180 In stock
50mg USD 450  USD500 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

Block lipid transport-1 (BLT-1) is a specific inhibitor of the SR-BI (Scavenger receptor, class B, type I) mediated lipid transfer. The compound inhibits both cellular selective lipid uptake of HDL cholesteryl ether and efflux of cellular cholesterol to HDL.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 241.4
Formula C12H23N3S
CAS Number 321673-30-7
Purity 99.46%
Solubility DMSO 30 mg/mL
Storage at -20°C
References

Reply to Padmanabhan and Dixit: Hepatitis C virus entry inhibitors for optimally boosting direct-acting antiviral-based treatments
Hirofumi Ohashi, et al. Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):E4527-E4529. PMID: 28512226.

Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity
Thomas J F Nieland, et al. Biochemistry. 2008 Jan 8;47(1):460-72. PMID: 18067275.

BLT-1, a specific inhibitor of the HDL receptor SR-BI, induces a copper-dependent phenotype during zebrafish development
Demetrio Raldua, et al. Toxicol Lett. 2007 Dec 10;175(1-3):1-7. PMID: 17890024.

Related HCV Protease Products
Merimepodib

Merimepodib, also known as VX-497, is an orally bioavailable IMPDH inhibitor with broad spectrum antiviral activities.

Inarigivir soproxil

Inarigivir soproxil, also known as SB 9200, is a novel agonist of innate immunity, which shows potent antiviral activity against resistant HCV variants.

Ombitasvir

Ombitasvir is a potent inhibitor of the hepatitis C virus protein NS5A, with EC50s of 0.82 to 19.3 pM against HCV genotypes 1 to 5 and 366 pM against genotype 6a.

Paritaprevir

Paritaprevir (ABT-450) is a potent non-structural protein 3/4A (NS3/4A) protease inhibitor with EC50 values of 1 and 0.21 nM for HCV 1a and 1b, respectively.

Velpatasvir

Velpatasvir is a second-generation NS5A inhibitor that inhibits hepatitis C viral replication through acting on the crucial "membranous web" that facilitates RNA replication.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: BLT-1, Block lipid transport-1 supplier, HCV Protease, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.