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Benzalkonium chloride

Cat. No. M20931
Benzalkonium chloride Structure
Size Price Availability Quantity
5g USD 50  USD50 In stock
10g USD 75  USD75 In stock
25g USD 95  USD95 In stock
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Quality Control & Documentation
Biological Activity

Benzalkonium chloride is a cationic surface-acting agent containing the quaternary ammonium group

Chemical Information
Molecular Weight 283.88
Formula C17H30ClN
CAS Number 63449-41-2
Form Semisolid
Solubility (25°C) Soluble in water and in ethanol
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Jean-Yves Maillard. J Appl Microbiol. Impact of benzalkonium chloride, benzethonium chloride and chloroxylenol on bacterial antimicrobial resistance

[2] Michael H Goldstein, et al. Eye (Lond). Ocular benzalkonium chloride exposure: problems and solutions

[3] Satoshi Seino, et al. Yakugaku Zasshi. [Effects of Benzalkonium Chloride in Ophthalmic Eyedrop Medications on Corneal Epithelium]

[4] Neil F Johnson. J Aerosol Med Pulm Drug Deliv. Pulmonary Toxicity of Benzalkonium Chloride

[5] Carol A Rasmussen, et al. J Ocul Pharmacol Ther. Benzalkonium chloride and glaucoma

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