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Cat. No. M20747
BAY-474 Structure
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Biological Activity

BAY-474 is an inhibitor of tyrosine-protein kinase c-Met and can act as an epigenetics probe.

Chemical Information
Molecular Weight 289.33
Formula C17H15N5
CAS Number 1033767-86-0
Solubility (25°C) DMSO 58 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Related c-Met Products
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Tepotinib Hydrochloride Hydrate is a potent, selective c-Met inhibitor with an IC50 of 4 nM and is more than 200-fold more selective for c-Met than for IRAK4, TrkA, Axl, IRAK1 and Mer.

Capmatinib hydrochloride

Capmatinib hydrochloride is a potent, orally active, selective, ATP-competitive c-Met kinase inhibitor that inhibits the phosphorylation of c-MET and downstream effector proteins of the c-MET pathway, with an IC50 value of 0.13 nM. In addition, Capmatinib hydrochloride In addition, Capmatinib hydrochloride can inhibit the proliferation and migration of c-Met-dependent tumor cells, and can effectively induce apoptosis (apoptosis), with anti-tumor activity.

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Adrixetinib is an inhibitor of protein tyrosine kinase with antineoplastic activity.

Abmole Inhibitor Catalog

Keywords: BAY-474 supplier, c-Met, inhibitors, activators

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