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BAY-474

Cat. No. M20747
BAY-474 Structure
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Biological Activity

BAY-474 is an inhibitor of tyrosine-protein kinase c-Met and can act as an epigenetics probe.

Chemical Information
Molecular Weight 289.33
Formula C17H15N5
CAS Number 1033767-86-0
Solubility (25°C) DMSO 58 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Related c-Met Products
Tepotinib Hydrochloride Hydrate

Tepotinib Hydrochloride Hydrate is a potent, selective c-Met inhibitor with an IC50 of 4 nM and is more than 200-fold more selective for c-Met than for IRAK4, TrkA, Axl, IRAK1 and Mer.

Capmatinib hydrochloride

Capmatinib hydrochloride is a potent, orally active, selective, ATP-competitive c-Met kinase inhibitor that inhibits the phosphorylation of c-MET and downstream effector proteins of the c-MET pathway, with an IC50 value of 0.13 nM. In addition, Capmatinib hydrochloride In addition, Capmatinib hydrochloride can inhibit the proliferation and migration of c-Met-dependent tumor cells, and can effectively induce apoptosis (apoptosis), with anti-tumor activity.

MET kinase-IN-4

MET kinase-IN-4 is an orally active Met kinase inhibitor. MET kinase-IN-4 has potent Met kinase inhibitory activity with an IC50 value of 1.9 nM. MET kinase-IN-4 can be used for the research of cancer.

Boditrectinib oxalate

Boditrectinib oxalate is a potent tyrosine kinase inhibitor. Boditrectinib oxalate serves as an antineoplastic agent. Boditrectinib oxalate is useful in the research of cancer, inflammation, neurodegenerative diseases and certain infectious diseases.

Adrixetinib 

Adrixetinib is an inhibitor of protein tyrosine kinase with antineoplastic activity.

  Catalog
Abmole Inhibitor Catalog




Keywords: BAY-474 supplier, c-Met, inhibitors, activators


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