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BAY 1217224

Cat. No. M21312
BAY 1217224  Structure
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Biological Activity

BAY 1217224 is a neutral non-premedication inhibitor of Thrombin with good oral pharmacokinetics.

Chemical Information
Molecular Weight 491.94
Formula C24H27ClFN3O5
CAS Number 1639886-32-0
Solubility (25°C) N/A
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Related Thrombopoietin/Thrombin Products
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Succinyl-(Pro58, D-Glu65)-Hirudin (56-65) (sulfated)

Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is a hirugen-like peptide, and has high affnity for thrombin than Hirugen, with a KD < 100 nM.

Thrombin receptor peptide ligand

Thrombin receptor peptide ligand is a thrombin receptor antagonist peptide that can be used as an antithrombotic agent.

Z-Gly-Pro-Arg-4MβNA

Z-Gly-Pro-Arg-4MβNA is the cleavage of the substrate of thrombin to release free 4-methoxy-2-naphthylamine (4MβNA).

  Catalog
Abmole Inhibitor Catalog




Keywords: BAY 1217224 supplier, Thrombopoietin/Thrombin, inhibitors, activators


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