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Atibuclimab

Cat. No. M25139

All AbMole products are for research use only, cannot be used for human consumption.

Atibuclimab Structure

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Quality Control & Documentation
Biological Activity

Atibuclimab, is a chimeric monoclonal antibody directed against CD14 and is composed of murine variable and human IgG4 Fc regions. Atibuclimab can be used for the research of amyotrophic lateral sclerosis. Atibuclimab attenuates LPS-induced symptoms and strongly inhibits LPS-induced proinflammatory cytokine release, while only delaying the release of the anti-inflammatory cytokines soluble TNF receptor type I and IL-1 receptor antagonist.

Chemical Information
CAS Number 2417175-94-9
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Dario Gelevski, et al. Muscle Nerve. Safety and activity of anti-CD14 antibody IC14 (atibuclimab) in ALS: Experience with expanded access protocol

[2] Robert D Henderson, et al. Medicine (Baltimore). Phase 1b dose-escalation, safety, and pharmacokinetic study of IC14, a monoclonal antibody against CD14, for the treatment of amyotrophic lateral sclerosis

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Keywords: Atibuclimab supplier, inhibitors, activators

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