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Arzoxifene hydrochloride

Cat. No. M28925

All AbMole products are for research use only, cannot be used for human consumption.

Arzoxifene hydrochloride Structure
Synonym:

LY353381 hydrochloride; SERM III hydrochloride

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Quality Control & Documentation
Biological Activity

Arzoxifene (LY353381) hydrocloride is a selective estrogen receptor modulator that is a potent estrogen antagonist in mammary and uterine tissue while acting as an estrogen agonist to maintain bone density and lower serum cholesterol.

Chemical Information
Molecular Weight 512.06
Formula C28H30ClNO4S
CAS Number 182133-27-3
Form Solid
Solubility (25°C) DMSO 25 mg/mL (ultrasonic and warming and heat to 60°C)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Steven R Goldstein, et al. Menopause. Gynecologic effects of arzoxifene in postmenopausal women with osteoporosis or low bone mass

[2] D L Kendler, et al. Osteoporos Int. Arzoxifene versus raloxifene: effect on bone and safety parameters in postmenopausal women with osteoporosis

[3] R W Downs Jr, et al. Osteoporos Int. Effects of arzoxifene on bone, lipid markers, and safety parameters in postmenopausal women with low bone mass

[4] Michael B Sporn. Clin Cancer Res. Arzoxifene: a promising new selective estrogen receptor modulator for clinical chemoprevention of breast cancer

[5] Cynthia L Bethea, et al. Psychoneuroendocrinology. Effects of oral estrogen, raloxifene and arzoxifene on gene expression in serotonin neurons of macaques

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Keywords: Arzoxifene hydrochloride, LY353381 hydrochloride; SERM III hydrochloride supplier, Estrogen Receptor, inhibitors, activators

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