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Bavdegalutamide (ARV-110) is an oral, specific androgen receptor (AR) PROTAC degrader. ARV-110 promotes ubiquitination and degradation of AR. ARV-110 degrades clinically relevant mutant AR proteins (WT AR, F876L, T877A, M896V and H874V) and retains activity in a high androgen environment in VCaP cells.
In vivo, ARV-110 (1 mg/kg; oral gavage QD) exhibits a greater than 90% AR degradation.
Biomed Chromatogr. 2025 Feb 08;39(3):e6090.
A Validated Liquid Chromatography–Tandem Mass Spectrometry Assay for the Determination of NX-5948 in Beagle Dog Plasma: Application to a Pharmacokinetic Study
Bavdegalutamide (ARV-110) purchased from AbMole
| Molecular Weight | 812.29 |
| Formula | C41H43ClFN9O6 |
| CAS Number | 2222112-77-6 |
| Solubility (25°C) | DMSO 16 mg/mL |
| Storage | -20°C, sealed |
[2] Cancer Discov. Proof-of-Concept with PROTACs in Prostate Cancer
[3] Yang Wang, et al. Acta Pharm Sin B. Degradation of proteins by PROTACs and other strategies
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