All AbMole products are for research use only, cannot be used for human consumption.
Aristolactam I is an AQP1 inhibitor and Aristolochic acid I metabolite. Aristolactam I downregulates Twist1 expression, increases E-cadherin expression, and activates the TGF-β/Smad signaling pathway. Aristolactam I is mainly used in the study of breast cancer and kidney diseases such as renal interstitial fibrosis.
| Molecular Weight | 293.27 |
| Formula | C17H11NO4 |
| CAS Number | 13395-02-3 |
| Solubility (25°C) | DMSO 10 mg/mL |
| Storage | 4°C, protect from light |
| Related AQP Products |
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| DFP00173
DFP00173 is a potent and selective aquaporin-3 (AQP3) inhibitor. DFP00173 is selective for AQP3 over the homologous AQP isoforms AQP7 and AQP9. DFP00173 inhibits mouse and human AQP3 with an IC50 of ∼0.1-0.4 μM. |
| TC AQP1 1
TC AQP1 1 (m-Phenylenediacrylic acid) is a potent AQP1 inhibitor. TC AQP1 1 inhibits AQP1-mediated water flux in oocytes, with an IC50 of 8 μM. |
| Z433927330
Z433927330 is a potent and selective inhibitor of Aquaporin-7 (AQP7), less potently inhibits AQP3 and AQPs9, with IC50s of ~0.2 µM, ~0.7 µM and ~1.1 µM for mAQP7, mAQP3 and mAQP9, respectively. |
| Bacopaside II
Bacopaside II, an extract from the medicinal herb Bacopa monnieri, blocks the Aquaporin-1 (AQP1) water channel and impairs migration of cells that express AQP1. Bacopaside II induces cell cycle arrest and apoptosis. |
| TGN 020
TGN 020 is a aquaporin 4 (AQP4) channel blocker. |
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Products are for research use only. Not for human use. We do not sell to patients.
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