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Arachidonic acid is subsequently metabolized to prostaglandins and thromboxanes by at least two cyclooxygenase (COX) isoforms, to leukotrienes and lipoxins by lipoxygenases, and to epoxyeicosatrienoic acids via cytochrome p450-catalyzed metabolism. Arachidonic acid and its metabolites play important roles in a variety of biological processes, including signal transduction, smooth muscle contraction, chemotaxis, cell proliferation and differentiation, and apoptosis. Arachidonic acid has been demonstrated to bind to the a subunit of G protein and inhibit the activity of Ras GTPase-activating proteins (GAPs). Cellular uptake of Arachidonic acid is energy dependent and involves protein-facilitated transport across the plasma membrane.
Arachidonic acid stimulates adhesion of MDA-MB-435 human metastatic cancer cells to extracellular matrix molecules (collagen IV and vitronectin) .
| Molecular Weight | 304.47 |
| Formula | C20H32O2 |
| CAS Number | 506-32-1 |
| Form | Liquid |
| Solubility (25°C) | DMSO: ≥ 30 mg/mL |
| Storage | -20°C, dry, sealed |
| Related Metabolite/Endogenous Metabolite Products |
|---|
| Isolithocholic acid
Isolithocholic acid (β-Lithocholic acid) is an isomer of Lithocholic acid. Isolithocholic acid, a bile acid, is formed by microbial metabolism of Lithocholic acid or Lithocholic acid 3α-sulfate. |
| 1-Palmitoyl-sn-glycero-3-phosphocholine
1-Palmitoyl-sn-glycero-3-phosphocholine is an lysophosphatidylcholine. 1-Palmitoyl-sn-glycero-3-phosphocholine exhibits proinflammatory activity. 1-Palmitoyl-sn-glycero-3-phosphocholine can be used in the research of atherosclerosis. |
| L-Citrulline DL-Malate
L-Citrulline DL-malate is an organic compound commonly used as a nutritional supplement. It boosts the body's production of nitrogen oxides, improves circulation and athletic performance, and reduces muscle fatigue. In addition, L-Citrulline DL-malate can be used in the field of agriculture to enhance plant immunity. |
| Creatine-d3
Creatine-d3 is the deuterium labeled Creatine. Creatine is an endogenous amino acid derivative, which plays an important role in cellular energy, especially in muscle and brain. |
| Creatinine-d3
Creatinine-d3 is a deuterium labeled Creatinine. Creatinine is a break-down product of creatine phosphate in muscle. |
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