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AQ-RA 741 is a high affinity, selective muscarinic M2 receptor antagonist (pKi values are 8.3, 7.7 and 6.82 for M2, M1 and M3 receptors, respectively). Displays cardioselectivity in vivo, over intestinal, tracheal and bladder muscarinic receptors; inhibits vagally and agonist-induced bradycardia.
| Molecular Weight | 463.62 |
| Formula | C27H37N5O2 |
| CAS Number | 123548-16-3 |
| Solubility (25°C) | 1eq. HCl 46.36 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Slemmer, et al. J Pharmacol Exp Ther. Bupropion is a nicotinic antagonist.
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