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AP20187

Cat. No. M13547

All AbMole products are for research use only, cannot be used for human consumption.

AP20187 Structure
Synonym:

B/B Homodimerizer

Size Price Availability Quantity
5mg USD 320  USD320 In stock
10mg USD 500  USD500 In stock
25mg USD 950  USD950 In stock
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Quality Control & Documentation
Biological Activity

AP20187 (B/B Homodimerizer) is a cell-permeable ligand used to dimerize FK506-binding protein (FKBP) fusion proteins and initiate biological signaling cascades and gene expression or disrupt protein-protein interactions.

Chemical Information
Molecular Weight 1482.75
CAS Number 195514-80-8
Solubility (25°C) Ethanol 100 mg/mL
DMSO ≥ 57 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Mikolaj Ogrodnik, et al. Aging Cell. Whole-body senescent cell clearance alleviates age-related brain inflammation and cognitive impairment in mice

[2] Xiaobing Yu, et al. Nat Commun. Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain

[3] Mikolaj Ogrodnik, et al. Cell Metab. Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

[4] Darren J Baker, et al. Nature. Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan

[5] Darren J Baker, et al. Nature. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

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Keywords: AP20187, B/B Homodimerizer supplier, inhibitors, activators

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