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Angoroside-C

Cat. No. M4286
Angoroside-C Structure
Size Price Availability Quantity
20mg USD 250  USD250 In stock
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Quality Control & Documentation
Biological Activity

Angoroside C is a phenylalanine extracted from Radix Scrophulariae, which is beneficial for ventricular remodeling.

Chemical Information
Molecular Weight 784.75
Formula C36H48O19
CAS Number 115909-22-3
Form Solid
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage 4°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Lina Su, et al. Infrared-assisted extraction followed by high performance liquid chromatography to determine angoroside C, cinnamic acid, and harpagoside content in Scrophularia ningpoensis

[2] Chenning Zhang, et al. Pharmacokinetics, Bioavailability, and Tissue Distribution Study of Angoroside C and Its Metabolite Ferulic Acid in Rat Using UPLC-MS/MS

[3] Yi-Fan Zhang, et al. Investigation of the In Vivo Metabolism of Sibirioside A and Angoroside C in Rats by HPLC-ESI-IT-TOF-MS n

[4] Wei Liang Gu, et al. The effect of angoroside C on pressure overload-induced ventricular remodeling in rats

[5] Ana Mara Daz, et al. Phenylpropanoid glycosides from Scrophularia scorodonia: in vitro anti-inflammatory activity

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