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ANG1005

Cat. No. M31338

All AbMole products are for research use only, cannot be used for human consumption.

ANG1005 Structure
Synonym:

Paclitaxel trevatide

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Quality Control & Documentation
Biological Activity

ANG1005 is a paclitaxel derivative as well as a peptide-coupled compound (PDC) consisting of three paclitaxel and Angiopep-2 covalently linked. In addition, ANG1005 is a modulator of LDLR and an inhibitor of mitosis and microtubule proteins.

Chemical Information
Molecular Weight 5127.33
Formula C256H306N32O81
CAS Number 1075214-55-9
Form Solid
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Fei Li, et al. Genes Dis. Targeting metastatic breast cancer with ANG1005, a novel peptide-paclitaxel conjugate that crosses the blood-brain-barrier (BBB)

[2] C C O'Sullivan, et al. Breast Cancer Res Treat. ANG1005 for breast cancer brain metastases: correlation between 18F-FLT-PET after first cycle and MRI in response assessment

[3] Fancy C Thomas, et al. Pharm Res. Uptake of ANG1005, a novel paclitaxel derivative, through the blood-brain barrier into brain and experimental brain metastases of breast cancer

[4] A Régina, et al. Br J Pharmacol. Antitumour activity of ANG1005, a conjugate between paclitaxel and the new brain delivery vector Angiopep-2

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Keywords: ANG1005, Paclitaxel trevatide supplier, inhibitors, activators

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