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Anetumab

Cat. No. M24861

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Anetumab Structure
Synonym:

Anti-MSLN Antibody

Size Price Availability Quantity
100ug USD 190  USD190 In stock
1mg USD 410  USD410 In stock
5mg USD 880  USD880 In stock
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Quality Control & Documentation
Biological Activity

Anetumab (Anti-MSLN Antibody) is an anti-mesothelin (MSLN) antibody. MSLN is a tumor-associated antigen. Anetumab can be used to synthesis Anetumab ravtansine, a MSLN-targeting antibody-drug conjugate (ADC). Anetumab can be used for the research of malignant tumor.

Immobilized human Mesothelin at 2 ug/mL can bind anetumab, EC50=0.01877 ug/mL.

Human Mesothelin CHO-K Cell Line were stained with anetumab and negative control protein respectively, washed and then followed by PE and analyzed with FACS, the EC50 is 0.915 ug/mL.

Chemical Information
CAS Number 1954758-84-9
Storage Store at ≤ -20℃ for 24 months. Avoid repeated freeze-thaw cycles.
References

[1] Vincent Chen, et al. Br J Cancer. Exploiting mesothelin in thymic carcinoma as a drυg delivery target for anetumab ravtansine

[2] Raffit Hassan, et al. J Clin Oncol. First-in-Human, Multicenter, Phase I Dose-Escalation and Expansion Study of Anti-Mesothelin Antibody-Drυg Conjugate Anetumab Ravtansine in Advanced or Metastatic Solid Tumors

[3] Maria Quanz, et al. Oncotarget. Anetumab ravtansine inhibits tumor growth and shows additive effect in combination with targeted agents and chemotherapy in mesothelin-expressing human ovarian cancer models

[4] Sven Golfier, et al. Mol Cancer Ther. Anetumab ravtansine: a novel mesothelin-targeting antibody-drυg conjugate cures tumors with heterogeneous target expression favored by bystander effect

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Keywords: Anetumab, Anti-MSLN Antibody supplier, inhibitors, activators

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