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AL 8697 is a potent and selective p38α inhibitor (IC50 = 6 nM). Exhibits 14-fold greater inhibition of p38α compared to p38β; also displays 300-fold selectivity for p38α compared to a panel of 91 kinases. Exhibits anti-inflammatory properties.
| Molecular Weight | 402.41 |
| Formula | C21H21F3N4O |
| CAS Number | 1057394-06-5 |
| Solubility (25°C) | DMSO 40.24 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Jin, et al. Biochemistry. Mechanisms of inward-rectifier K+ channel inhibition by tertiapin-Q.
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