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AH 6809

Cat. No. M10680
AH 6809  Structure
Synonym:

6-Isopropoxy-9-xanthone-2-carboxylicacid

Size Price Availability Quantity
5mg USD 70  USD70 In stock
10mg USD 120  USD120 In stock
50mg USD 420  USD420 In stock
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Quality Control & Documentation
Biological Activity

AH 6809 is an antagonist of EP and DP receptors against cloned humans EP1,EP2,EP3-III and DP receptors Ki Values were 1217, 1150, 1597, and 1415 nM, respectively, for mice EP2 receptors Ki The value is 350 nM.

Chemical Information
Molecular Weight 298.29
Formula C17H14O5
CAS Number 33458-93-4
Solubility (25°C) DMSO ≥ 20 mg/mL
Storage RT, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Chen-Lu Liao, et al. Int J Ophthalmol. Identification and validation of tumor microenvironment-related lncRNA prognostic signature for uveal melanoma

[2] Kun Liu, et al. Microb Pathog. Prostaglandin E2 promotes Staphylococcus aureus infection via EP4 receptor in bovine endometrium

[3] Dong-Dong Gao, et al. Am J Physiol Cell Physiol. Cellular mechanism underlying oxytocin-stimulated Cl - secretion in rat cauda epididymal epithelium

[4] D F Woodward, et al. Biochem Pharmacol. 6-Isopropoxy-9-oxoxanthene-2-carboxylic acid (AH 6809), a human EP2 receptor antagonist

[5] H Matsumura, et al. Proc Natl Acad Sci U S A. Evidence that brain prostaglandin E2 is involved in physiological sleep-wake regulation in rats

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  Catalog
Abmole Inhibitor Catalog




Keywords: AH 6809 , 6-Isopropoxy-9-xanthone-2-carboxylicacid supplier, Prostaglandin Receptor, inhibitors, activators


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