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Terutroban

Cat. No. M3951

All AbMole products are for research use only, cannot be used for human consumption.

Terutroban Structure
Synonym:

S-18886

Size Price Availability Quantity
5mg USD 55 In stock
10mg USD 85 In stock
25mg USD 200 In stock
50mg USD 350 In stock
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Quality Control & Documentation
Biological Activity

Terutroban significantly protected retinal vascularity from ischaemia in experimental diabetes, and this result could be attributed not only to its antiplatelet/antithrombotic activities but also to its vascular properties.TP-receptor blockade with terutroban decreases portal pressure in cirrhosis.This effect is due to decreased hepatic resistance, which in CCl4 -cirrhotic rats was linked to decreased hepatic fibrosis, but not in BDL rats, in which the main mediator appeared to be an enhanced eNOS-dependent vasodilatation, which was not liver-selective, as it was associated with decreased arterial pressure.

Chemical Information
Molecular Weight 407.92
Formula C20H22ClNO4S
CAS Number 165538-40-9
Form Solid
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] De La Cruz JP, et al. Diabetes Metab Res Rev. Effects of terutroban, a thromboxane/prostaglandin endoperoxide receptor antagonist, on retinal vascularity in diabetic rats.

[2] Rosado E, et al. Diabetes Metab Res Rev. Terutroban, a TP-receptor antagonist, reduces portal pressure in cirrhotic rats.

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Keywords: Terutroban, S-18886 supplier, Prostaglandin Receptor, inhibitors, activators

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