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AEG 3482 is a inhibitor of c-jun N-terminal kinase (JNK) signaling. Binds Hsp90 and facilitates HSF1 release, induces expression of Hsp70, which in turn blocks JNK activation and JNK-dependent apoptosis. Antiapoptotic; inhibits NGF withdrawal-induced death in SCG neurons (EC50 = 20 μM).
| Molecular Weight | 280.33 |
| Formula | C10H8N4O2S2 |
| CAS Number | 63735-71-7 |
| Solubility (25°C) | DMSO 28.03 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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