ADP (Adenosine 5'-diphosphate) is a nucleoside diphosphate, which is the product of ATP dephosphorylation by ATPase. Is necessary for the flow of energy in living cells.
| Molecular Weight | 427.2 |
| Formula | C10H15N5O10P2 |
| CAS Number | 58-64-0 |
| Solubility (25°C) | DMSO ≥ 40 mg/mL |
| Storage | 4°C, protect from light, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] R N Puri, et al. Crit Rev Biochem Mol Biol. ADP-induced platelet activation
[3] H C Lee, et al. Biochimie. Cyclic ADP-ribose and its metabolic enzymes
[4] R W Colman. Ann N Y Acad Sci. ADP receptors in platelets
[5] C Gachet, et al. Nouv Rev Fr Hematol (1978). ADP induced blood platelet activation: a review
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