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ACT-462206

Cat. No. M8523

All AbMole products are for research use only, cannot be used for human consumption.

ACT-462206 Structure
Size Price Availability Quantity
10mg USD 170 In stock
25mg USD 355 In stock
50mg USD 560 In stock
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Quality Control & Documentation
Biological Activity

ACT-462206 is a orally active, brain penetrant, potent and selective dual orexin1/2 receptor antagonist (DORA). ACT-462206 decreases wakefulness, decreases sleep latency, and increases sleep efficacy in rats and dogs.

Chemical Information
Molecular Weight 388.48
Formula C20H24N2O4S
CAS Number 1361321-96-1
Solubility (25°C) DMSO: 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Rohan Umesh Parekh, et al. Hypothalamic kinin B1 receptor mediates orexin system hyperactivity in neurogenic hypertension

[2] Christoph Boss. 20 Years of Medicinal Chemistry - Always Look at the Bright Side (of Life)

[3] Christoph Boss, et al. Structure-activity relationship, biological, and pharmacological characterization of the proline sulfonamide ACT-462206: a potent, brain-penetrant dual orexin 1/orexin 2 receptor antagonist

[4] Matthias Hoch, et al. Entry-into-humans study with ACT-462206, a novel dual orexin receptor antagonist, comparing its pharmacodynamics with almorexant

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Keywords: ACT-462206 supplier, inhibitors, activators

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