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ACT-462206 is a orally active, brain penetrant, potent and selective dual orexin1/2 receptor antagonist (DORA). ACT-462206 decreases wakefulness, decreases sleep latency, and increases sleep efficacy in rats and dogs.
| Molecular Weight | 388.48 |
| Formula | C20H24N2O4S |
| CAS Number | 1361321-96-1 |
| Solubility (25°C) | DMSO: 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Christoph Boss. 20 Years of Medicinal Chemistry - Always Look at the Bright Side (of Life)
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