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Acolbifene hydrochloride

Cat. No. M45336

All AbMole products are for research use only, cannot be used for human consumption.

Acolbifene hydrochloride Structure
Synonym:

EM-652 hydrochloride; SCH 57068 hydrochloride

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Quality Control & Documentation
Biological Activity

Acolbifene hydrochloride is an active metabolite of EM800 and an orally available, selective estrogen receptor modulator (SERM) that inhibits estradiol-induced ERα (IC50 = 2 nM) and ERβ (IC50 = 0.4 nM) transcriptional activity, has significant anti-estrogenic effects on the mammary gland and uterus, and has anticancer activity. possesses anticancer activity.

Chemical Information
Molecular Weight 494.02
Formula C29H32ClNO4
CAS Number 252555-01-4
Form Solid
Solubility (25°C) DMSO >100 mg/mL
Storage 4°C, dry, sealed
References

[1] Ezequiel Calvo, et al. Breast Cancer Res Treat. Specific transcriptional response of four blockers of estrogen receptors on estradiol-modulated genes in the mouse mammary gland

[2] Matthieu Gutman, et al. Int J Cancer. Comparison of the effects of EM-652 (SCH57068), tamoxifen, toremifene, droloxifene, idoxifene, GW-5638 and raloxifene on the growth of human ZR-75-1 breast tumors in nude mice

[3] Csaba Gajdos, et al. Clin Breast Cancer. Selective estrogen receptor modulators as a new therapeutic drug group: concept to reality in a decade

[4] J I Schafer, et al. Cancer Res. The interaction of raloxifene and the active metabolite of the antiestrogen EM-800 (SC 5705) with the human estrogen receptor

[5] J Simard, et al. Cancer Res. Blockade of the stimulatory effect of estrogens, OH-tamoxifen, OH-toremifene, droloxifene, and raloxifene on alkaline phosphatase activity by the antiestrogen EM-800 in human endometrial adenocarcinoma Ishikawa cells

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Keywords: Acolbifene hydrochloride, EM-652 hydrochloride; SCH 57068 hydrochloride supplier, Estrogen Receptor, inhibitors, activators

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