Acepromazine is a phenothiazine antipsychotic compound commonly used as a veterinary drug (horse, dog, and cat). The compound is a similar antipsychotic compound chlorpromazine (#C8138). The drug is thought to block dopamine receptors in the brain. Recently, the compound was found to inhibit the expression of the ABCG2 transporter, whose overexpression in tumors is associated with drug resistance.
| Molecular Weight | 442.53 |
| Formula | C19H22N2OS · C4H4O4 |
| CAS Number | 3598-37-6 |
| Solubility (25°C) | Water: ≥10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[4] Fiona I Schneiders, et al. Acepromazine pharmacokinetics: a forensic perspective
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