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AC710 is a potent, selective and orally active platelet-derived growth factor receptor-family (PDGFR) kinase inhibitor with potential anticancer activity. AC710 has IC50 values of 1.2, 2, 7.7 and 10.5 nM for KIT, FLT3, PDGFRβ and CSF1R respectively.
AC710 causes tumor regression of leukemia cell xenografts in mice. AC710 exhibits a significant impact on disease in a dose-dependent fashion in a mouse collagen-induced arthritis (CIA) model, at a dose as low as 3 mg/ kg for 15 days (day 0-14). At 10 and 30 mg/kg, AC710 demonstrates equivalent or slightly better efficacy in reducing the joint swelling and inflammation at a safe dose.
| Molecular Weight | 562.7 |
| Formula | C31H42N6O4 |
| CAS Number | 1351522-04-7 |
| Solubility (25°C) | DMSO ≥ 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related VEGFR/PDGFR Products |
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| SU5208
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| VEGFR-IN-1
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| (Rac)-SAR131675
(Rac)-SAR131675 is the racemate of SAR131675. |
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