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AC480 (BMS-599626)

Cat. No. M20388

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AC480 (BMS-599626) Structure

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Biological Activity

AC480 (BMS-599626) is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, ~8-fold less potent to HER4, >100-fold to VEGFR2, c-Kit, Lck, MET etc. Phase 1.

Chemical Information
Molecular Weight 530.55
Formula C27H27FN8O3
CAS Number 714971-09-2
Solubility (25°C) DMSO 113 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] J-C Soria, et al. Ann Oncol. Phase I safety, pharmacokinetic and pharmacodynamic trial of BMS-599626 (AC480), an oral pan-HER receptor tyrosine kinase inhibitor, in patients with advanced solid tumors

[2] J-C Soria, et al. Ann Oncol. Phase I safety, pharmacokinetic and pharmacodynamic trial of BMS-599626 (AC480), an oral pan-HER receptor tyrosine kinase inhibitor, in patients with advanced solid tumors

[3] Mylin A Torres, et al. Invest New Drugs. AC480, formerly BMS-599626, a pan Her inhibitor, enhances radiosensitivity and radioresponse of head and neck squamous cell carcinoma cells in vitro and in vivo

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Keywords: AC480 (BMS-599626) supplier, EGFR/HER2, inhibitors, activators

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