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Nonpeptide GPR14 / urotensin-UII (UII) receptor agonist that has an EC50 of 300 nM at the human UII receptor (h-UTR). AC-7954 has been shown to exist in two conformations, A and B; both conformations have a pharmacophoric distance within 0.5 Å of P5U, a potent peptidic UII agonist.
| Molecular Weight | 366.28 |
| Formula | C19H20ClNO2 · HCl |
| CAS Number | 477313-09-0 |
| Solubility (25°C) | Water: ~28 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Fredrik Lehmann, et al. Novel potent and efficacious nonpeptidic urotensin II receptor agonists
[3] Fredrik Lehmann, et al. Isochromanone-based urotensin-II receptor agonists
[4] Masaaki Mori. Development of therapeutic agents related to urotensin II
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