Abscisic Acid is a plant hormone and growth regulator that is involved in several physiological mechanisms including seed dormancy, leaf abscission, stomatal movement, and plant stress responses. Through complex interactions with several intracellular signaling systems, it can regulate the expression of hundreds of plant genes.
| Molecular Weight | 264.32 |
| Formula | C15H20O4 |
| CAS Number | 21293-29-8 |
| Solubility (25°C) | DMSO ≥ 10 mg/mL |
| Storage | 2-8°C, dry, protect from light |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Kong Chen, et al. Abscisic acid dynamics, signaling, and functions in plants
[3] Ting Dong, et al. Abscisic acid: biosynthesis, inactivation, homoeostasis and signalling
[4] Sean R Cutler, et al. Abscisic acid: emergence of a core signaling network
[5] Eiji Nambara, et al. Abscisic acid biosynthesis and catabolism
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