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ABR-238901

Cat. No. M11435

All AbMole products are for research use only, cannot be used for human consumption.

ABR-238901 Structure

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Quality Control & Documentation
Biological Activity

Abr-238901 is an orally effective S100A8/A9 blocker that inhibits the interaction of S100A8/A9 with its receptors RAGE (receptor for advanced glycation end products) and TLR4(Toll-like receptor 4). Abr-238901 has the potential to be used in myocardial infarction (MI) research.

Chemical Information
Molecular Weight 394.63
Formula C11H9BrClN3O4S
CAS Number 1638200-22-2
Solubility (25°C) DMSO ≥ 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Feng Sun, et al. Exp Ther Med. S100A9 blockade improves the functional recovery after spinal cord injury via mediating neutrophil infiltration

[2] Zhiyi Ding, et al. Int J Mol Sci. Targeting S100A9 Reduces Neutrophil Recruitment, Inflammation and Lung Damage in Abdominal Sepsis

[3] Goran Marinković, et al. Circ Res. S100A9 Links Inflammation and Repair in Myocardial Infarction

[4] Goran Marinković, et al. Eur Heart J. Inhibition of pro-inflammatory myeloid cell responses by short-term S100A9 blockade improves cardiac function after myocardial infarction

[5] Kim De Veirman, et al. Cancer Immunol Res. Extracellular S100A9 Protein in Bone Marrow Supports Multiple Myeloma Survival by Stimulating Angiogenesis and Cytokine Secretion

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Keywords: ABR-238901 supplier, inhibitors, activators

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