Free shipping on all orders over $ 500

ABR-238901

Cat. No. M11435
ABR-238901  Structure
Size Price Availability Quantity
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Abr-238901 is an orally effective S100A8/A9 blocker that inhibits the interaction of S100A8/A9 with its receptors RAGE (receptor for advanced glycation end products) and TLR4(Toll-like receptor 4). Abr-238901 has the potential to be used in myocardial infarction (MI) research.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 394.63
Formula C11H9BrClN3O4S
CAS Number 1638200-22-2
Purity >99%
Solubility DMSO ≥ 20 mg/mL
Storage at -20°C
Related Products
RP-6306

RP-6306 is the only inhibitor of PKMYT1 currently available in the clinic, which is synthetically fatal to CCNE1 amplification, FBXW7 deletion or other specific mutations.

Myxothiazol

Myxothiazol, an antifungal antibiotic, is an inhibitor of mitochondrial electron transport chain complex III (Complex III or Bc1 complex).

WGA

Wheat agglutinin (WGA) is isolated from wheat (Triticum vulgaris, Weat germ), WGA selectively binds to glycoproteins and glycolipids of n-acetylglucosamine (GlcNAc) and n-acetylneuraminine (sialic acid) residues.

Antide

Sequence:Ac-D2Nal-DCpa-DPal-Ser-Lys(nicotinoyl)-DLys(nicotinoyl)-Leu-Lys(isopropyl)-Pro-DAla-NH2

NE-CARBOXYMETHYL-L-LYSINE

NE-CARBOXYMETHYL-L-LYSINE

  Catalog
Abmole Inhibitor Catalog




Keywords: ABR-238901 supplier, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.