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Abicipar pegol

Cat. No. M24615
Abicipar pegol Structure

AGN-150998; MP0112

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Biological Activity

Abicipar pegol (AGN-150998, MP0112) is an anti-VEGF DARPin molecule, a novel class of small proteins containing ankyrin repeat domains engineered to bind with high specificity and affinity to target proteins. Abicipar pegol effectively inhibits angiogenesis and vascular permeability and is used in the study of diseases related to ocular inflammation by intravitreal injection, reducing mean retinal thickness and leakage area.

Chemical Information
CAS Number 1327278-94-3
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Rehan M Hussain, et al. Expert Opin Biol Ther. Abicipar pegol for neovascular age-related macular degeneration

[2] Lorenzo Ferro Desideri, et al. Expert Opin Investig Drugs. Abicipar pegol: an investigational anti-VEGF agent for the treatment of wet age-related macular degeneration

[3] Claudio Campa. Curr Drug Targets. New Anti-VEGF Drυgs in Ophthalmology

[4] Ashish Sharma, et al. Eye (Lond). Abicipar pegol: the non-monoclonal antibody anti-VEGF

[5] Elad Moisseiev, et al. Eye (Lond). Abicipar pegol-a novel anti-VEGF therapy with a long duration of action

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Keywords: Abicipar pegol, AGN-150998; MP0112 supplier, VEGFR/PDGFR, inhibitors, activators

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