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Cat. No. M24919
Abelacimab Structure


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Biological Activity

Abelacimab (MAA868) is a fully human IgG1 monoclonal antibody that binds with high affinity to the catalytic structural domain of FXI and locks it in the zymogen conformation, thereby preventing its activation by FXIIa or thrombin. Abelacimab can be used in thromboembolic disease studies.

Chemical Information
CAS Number 2098724-83-3
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Benjamin D Gallagher. N Engl J Med. Abelacimab for Prevention of Venous Thromboembolism

[2] Sudhamshi Toom, et al. N Engl J Med. Abelacimab for Prevention of Venous Thromboembolism

[3] Xiang Wang. N Engl J Med. Abelacimab for Prevention of Venous Thromboembolism

[4] B Alexander Yi, et al. J Thromb Haemost. Pharmacokinetics and pharmacodynamics of Abelacimab (MAA868), a novel dual inhibitor of Factor XI and Factor XIa

[5] Peter Verhamme, et al. N Engl J Med. Abelacimab for Prevention of Venous Thromboembolism

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Abmole Inhibitor Catalog

Keywords: Abelacimab, MAA868 supplier, Factor Xa, inhibitors, activators

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