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A12B4C3

Cat. No. M6383

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A12B4C3 Structure

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Quality Control & Documentation
Biological Activity

A12B4C3 is a potent and selective polynucleotide kinase/phosphatase (PNKP) inhibitor (IC50 = 60 nM). Displays no effect on calcineurin, protein PP-1 or APTX. Interrupts DNA repair and enhances radiosensitivity of human A549 lung carcinoma and MDA-MB-231 cells.

Chemical Information
Molecular Weight 534.65
Formula C30H38N4O5
CAS Number 1005129-80-5
Solubility (25°C) DMSO 53.47 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Dennis G Hall, et al. Multicomponent Hetero-[4 + 2] Cycloaddition/Allylboration Reaction: From Natural Product Synthesis to Drug Discovery

[2] Arman Zereshkian, et al. The human polynucleotide kinase/phosphatase (hPNKP) inhibitor A12B4C3 radiosensitizes human myeloid leukemia cells to Auger electron-emitting anti-CD123 ¹¹¹In-NLS-7G3 radioimmunoconjugates

[3] Gary K Freschauf, et al. Mechanism of action of an imidopiperidine inhibitor of human polynucleotide kinase/phosphatase

[4] Gary K Freschauf, et al. Identification of a small molecule inhibitor of the human DNA repair enzyme polynucleotide kinase/phosphatase

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Abmole Inhibitor Catalog




Keywords: A12B4C3 supplier, inhibitors, activators

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