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8,9-Dehydrothymol isobutyrate

Cat. No. M17023
8,9-Dehydrothymol isobutyrate Structure
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Quality Control & Documentation
Biological Activity

8,9-Dehydrothymol isobutyrate (Oil)

Chemical Information
CAS Number 38146-79-1
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hctor M Arreaga-Gonzlez, et al. J Nat Prod. Methodology for the Absolute Configuration Determination of Epoxythymols Using the Constituents of Piptothrix areolare

[2] Celia Bustos-Brito, et al. Molecules. Antidiarrheal Thymol Derivatives from Ageratina glabrata. Structure and Absolute Configuration of 10-Benzoyloxy-8,9-epoxy-6-hydroxythymol Isobutyrate

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