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Fmoc-L-glutamic acid 5-tert-butyl ester

Cat. No. M39224
Fmoc-L-glutamic acid 5-tert-butyl ester Structure
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Biological Activity

Fmoc-L-glutamic acid 5-tert-butyl ester is a glutamic acid derivative.

Chemical Information
Molecular Weight 425.47
Formula C24H27NO6
CAS Number 71989-18-9
Form Solid
Solubility (25°C) DMSO 90 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Cui Ma et al. Environ Pollut. Catalytic ozonation of 2, 2'-methylenebis (4-methyl-6-tert-butylphenol) over nano-Fe3O4@cow dung ash composites: Optimization, toxicity, and degradation mechanisms

[2] Hongru Feng et al. Sci Total Environ. Estrogenic activity of benzotriazole UV stabilizers evaluated through in vitro assays and computational studies

[3] Edwar Cortés et al. Acta Crystallogr C Struct Chem. Octyl 1-(5-tert-butyl-1H-pyrazol-3-yl)-2-(4-chlorophenyl)-1H-benzimidazole-5-carboxylate: complex sheets built from N-H···N, C-H···N and C-H···O hydrogen bonds

[4] Karuthapandi Selvakumar et al. Chemistry. Synthesis of anionic hypervalent cyclic selenenate esters: relevance to the hypervalent intermediates in nucleophilic substitution reactions at the selenium(II) center

[5] Nicola Micale et al. J Med Chem. Novel potent AMPA/kainate receptor antagonists: synthesis and anticonvulsant activity of a series of 2-[(4-alkylsemicarbazono)-(4-amino-phenyl)methyl]-4,5-methylenedioxyphenylacetic acid alkyl esters

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