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6-Thioinosine Phosphate

Cat. No. M42994
6-Thioinosine Phosphate Structure
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Biological Activity

6-Thioinosine Phosphate (Thioinosinic acid) is an intermediate metabolite of azathioprine.

Chemical Information
Molecular Weight 364.27
Formula C10H13N4O7PS
CAS Number 53-83-8
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Masahiro Kaneko et al. Biochem Biophys Res Commun. Steroid hormones are novel nucleoside transport inhibitors by competition with nucleosides for their transporters

[2] M R ATKINSON et al. Biochem J. INHIBITION BY 6-MERCAPTOPURINE OF PURINE PHOSPHORIBOSYLTRANSFERASES FROM EHRLICH ASCITES-TUMOUR CELLS THAT ARE RESISTANT TO THE DRUG

[3] M Kadokura et al. J Org Chem. Synthesis of 4-thiouridine, 6-thioinosine, and 6-thioguanosine 3',5'-O-bisphosphates as donor molecules for RNA ligation and their application to the synthesis of photoactivatable TMG-capped U1 snRNA fragments

[4] M R Atkinson et al. Biochem J. Inhibition of adenylosuccinate synthetase and adenylosuccinate lyase from Ehrlich ascites-tumour cells by 6-thioinosine 5'-phosphate

[5] R B Meyer Jr et al. J Med Chem. 2'-O-Acyl-6-thioinosine cyclic 3',5'-phosphates as prodrugs of thioinosinic acid

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Keywords: 6-Thioinosine Phosphate supplier, inhibitors, activators

 
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