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6-Ketocholestanol

Cat. No. M25492
6-Ketocholestanol Structure
Synonym:

3β-Hydroxy-5α-cholestan-6-one

Size Price Availability
5mg USD 160  USD160 1-2 Weeks
10mg USD 250  USD250 1-2 Weeks
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Quality Control & Documentation
Biological Activity

6-Ketocholestanol is a recoupler for mitochondria, chromatophores and cytochrome oxidase proteoliposomes. 6-Ketocholestanol increases the membrane dipole potential.

Chemical Information
Molecular Weight 402.65
Formula C27H46O2
CAS Number 1175-06-0
Form Solid
Solubility (25°C) DMSO 90 mg/mL
Storage Powder -20°C
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Vera G Grivennikova, et al. Biochim Biophys Acta Bioenerg. Inhibition of respiratory complex I by 6-ketocholestanol: Relevance to recoupling action in mitochondria

[2] Bungo Shirouchi, et al. Cytotechnology. 6-Ketocholestanol suppresses lipid accumulation by decreasing FASN gene expression through SREBP-dependent regulation in HepG2 cells

[3] Barbara G Auner, et al. Int J Pharm. Interaction of phloretin and 6-ketocholestanol with DPPC-liposomes as phospholipid model membranes

[4] C Valenta, et al. Eur J Pharm Biopharm. Phloretin and 6-ketocholestanol: membrane interactions studied by a phospholipid/polydiacetylene colorimetric assay and differential scanning calorimetry

[5] A A Starkov, et al. Biochim Biophys Acta. 6-Ketocholestanol is a recoupler for mitochondria, chromatophores and cytochrome oxidase proteoliposomes

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Keywords: 6-Ketocholestanol, 3β-Hydroxy-5α-cholestan-6-one supplier, inhibitors, activators


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