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6-Hydroxydopamine hydrochloride

Cat. No. M7832
6-Hydroxydopamine hydrochloride Structure
Synonym:

6-Hydroxydopamine hydrochloride; 6-OHDA hydrochloride

Size Price Availability Quantity
5mg USD 50  USD50 In stock
10mg USD 90  USD90 In stock
50mg USD 210  USD210 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

6-Hydroxydopamine hydrochloride is an antagonist of the neurotransmitter dopamine.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 205.64
Formula (HO)3C6H2CH2CH2NH2.HCl
CAS Number 28094-15-7
Purity >97%
Solubility Water: ≥50 mg/mL
Storage at -20°C
References

[1] Qian Xu, et al. Effect of Roucongrong (Herba Cistanches Deserticolae) decoction on the substantia nigra through Wnt/β-catenin signaling pathway in rats with Parkinson's disease induced by 6-hydroxydopamine hydrochloride

[2] Monika Pichla, et al. Nitroxide Radical-Containing Redox Nanoparticles Protect Neuroblastoma SH-SY5Y Cells against 6-Hydroxydopamine Toxicity

[3] Wenjie Wang, et al. 6-Hydroxydopamine upregulates iron regulatory protein 1 by activating certain protein kinase C isoforms in the dopaminergic MES23.5 cell line

[4] H Cambridge, et al. Investigation of 6-hydroxydopamine-induced plasma extravasation in rat skin

[5] K J Lookingland, et al. Comparative effects of the neurotoxins N-chloroethyl-N-ethyl-2-bromobenzylamine hydrochloride (DSP4) and 6-hydroxydopamine on hypothalamic noradrenergic, dopaminergic and 5-hydroxytryptaminergic neurons in the male rat

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Keywords: 6-Hydroxydopamine hydrochloride, 6-Hydroxydopamine hydrochloride; 6-OHDA hydrochloride supplier, Dopamine Receptor, inhibitors

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