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5-Ph-IAA 

Cat. No. M28809

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5-Ph-IAA  Structure
Size Price Availability Quantity
5mg USD 70  USD70 In stock
10mg USD 120  USD120 In stock
25mg USD 240  USD240 In stock
50mg USD 400  USD400 In stock
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Quality Control & Documentation
Biological Activity

5-Ph-IAA is a derivative of IAA. 5-Ph-IAA, a ligand, establishes the auxin-inducible degron 2 (AID2) system together with an OsTIR1 (F74G) mutant. AID2 induces rapid and efficient depletion of mAID-fused proteins to study protein function in living cells, causing tumor suppression.

Chemical Information
Molecular Weight 251.28
Formula C16H13NO2
CAS Number 168649-23-8
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Takefumi Negishi, et al. Genetics. The auxin-inducible degron 2 (AID2) system enables controlled protein knockdown during embryogenesis and development in Caenorhabditis elegans

[2] Kelly Hills-Muckey, et al. Genetics. An engineered, orthogonal auxin analog/AtTIR1(F79G) pairing improves both specificity and efficacy of the auxin degradation system in Caenorhabditis elegans

[3] Yuichiro Saito, et al. Curr Protoc. Targeted Protein Depletion Using the Auxin-Inducible Degron 2 (AID2) System

[4] Aisha Yesbolatova, et al. Nat Commun. The auxin-inducible degron 2 technology provides sharp degradation control in yeast, mammalian cells, and mice

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Keywords: 5-Ph-IAA  supplier, inhibitors, activators

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