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5-Methyltetrahydrofolic acid

Cat. No. M14354

All AbMole products are for research use only, cannot be used for human consumption.

5-Methyltetrahydrofolic acid Structure
Synonym:

5-Methyl THF

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Quality Control & Documentation
Biological Activity

5-Methyltetrahydrofolic acid (5-Methyl THF) is a biologically active form of folic acid. 5-Methyltetrahydrofolic acid is a methylated derivate of tetrahydrofolate. 5-Methyltetrahydrofolic acid is the predominant natural dietary folate and the principal form of folate in plasma and cerebrospinal fluid.

Chemical Information
Molecular Weight 459.46
CAS Number 134-35-0
Solubility (25°C) DMSO 83.33 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Emanuela Pannia, et al. [6 S]-5-Methyltetrahydrofolic Acid and Folic Acid Pregnancy Diets Differentially Program Metabolic Phenotype and Hypothalamic Gene Expression of Wistar Rat Dams Post-Birth

[2] Rima Obeid, et al. Pharmacokinetics of Sodium and Calcium Salts of (6S)-5-Methyltetrahydrofolic Acid Compared to Folic Acid and Indirect Comparison of the Two Salts

[3] Kelsey M Cochrane, et al. Is natural (6S)-5-methyltetrahydrofolic acid as effective as synthetic folic acid in increasing serum and red blood cell folate concentrations during pregnancy? A proof-of-concept pilot study

[4] Francesco Scaglione, et al. Folate, folic acid and 5-methyltetrahydrofolate are not the same thing

[5] Klaus Pietrzik, et al. Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics

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Keywords: 5-Methyltetrahydrofolic acid, 5-Methyl THF supplier, Metabolite/Endogenous Metabolite, inhibitors, activators

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