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Cat. No. M21711
5-FAM SE Structure

5-Carboxyfluorescein succinimidyl ester

Size Price Availability Quantity
5mg USD 85  USD85 In stock
10mg USD 120  USD120 In stock
25mg USD 220  USD220 In stock
50mg USD 380  USD380 In stock
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Quality Control & Documentation
Biological Activity

5-FAM SE is a green fluorescent labeling reagent used for labeling peptides, proteins and nucleotides. 5-FAM SE can react with amines and can yield stable amine conjugates. 5-FAM SE (5-Carboxyfluorescein succinimidyl ester) is chosen as the labeling reagent to precapillary derivatize the two marker aminohydroxyphenylalanine (AHP) isomers produced after reductive hydrolysis of pheomelanin with hydriodic acid.

Chemical Information
Molecular Weight 473.39
Formula C25H15NO9
CAS Number 92557-80-7
Solubility (25°C) DMSO 20 mg/mL
Storage -20°C, protect from light, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Koujun Zhu, et al. J Biomed Nanotechnol. Novel Au-Se Nanoprobes for Specific Thrombin Detection in Diagnosis of Lung Cancer

[2] Qianqian Zhang, et al. Se Pu. Inhibitor screening and selectivity assessment against multiple cellular protein kinases by capillary electrophoresis with laser-induced fluorescence detection

[3] H-J Lin, et al. Eye (Lond). The association between lumican gene polymorphisms and high myopia

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Keywords: 5-FAM SE, 5-Carboxyfluorescein succinimidyl ester supplier, Fluorescent Dye, inhibitors, activators

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