5-FAM SE is a green fluorescent labeling reagent used for labeling peptides, proteins and nucleotides. 5-FAM SE can react with amines and can yield stable amine conjugates. 5-FAM SE (5-Carboxyfluorescein succinimidyl ester) is chosen as the labeling reagent to precapillary derivatize the two marker aminohydroxyphenylalanine (AHP) isomers produced after reductive hydrolysis of pheomelanin with hydriodic acid.
|Solubility (25°C)||DMSO 20 mg/mL|
|Storage||-20°C, protect from light, sealed|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 Koujun Zhu, et al. J Biomed Nanotechnol. Novel Au-Se Nanoprobes for Specific Thrombin Detection in Diagnosis of Lung Cancer
 Qianqian Zhang, et al. Se Pu. Inhibitor screening and selectivity assessment against multiple cellular protein kinases by capillary electrophoresis with laser-induced fluorescence detection
 H-J Lin, et al. Eye (Lond). The association between lumican gene polymorphisms and high myopia
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ANTS is a fluorescent dye. ANTS and DPX are encapsulated in liposomes can be an effective approach for measuring membrane leakage.
Pafolacianine, also known as OTL0038 and OTL-38, is a folate receptor-directing imaging agent. Pafolacianine (OTL 38) is used in detecting ovarian cancer lesions.
Phalloidin-retramethylrhodamine is an orange fluorescent probe (ex/em = 546/575 nm) that selectively binds to F-actin. It can be used to localize actin filaments in living or fixed cells, as well as for visualizing individual actin filaments in vitro.
6-TAMRA has been a widely used fluorophore for preparing bioconjugates, especially fluorescent antibody and avidin derivatives used in immunochemistry. The carboxylic acid of 6-TAMRA has also achieved prominence as a dye for oligonucleotide labeling and automated DNA sequencing applications.
5-TAMRA is a pH-insensitive orange-red fluorescence (approximate excitation/emission maxima ~546/579) with good photostability.
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