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4-Methylumbelliferyl α-L-arabinofuranoside

Cat. No. M42420
4-Methylumbelliferyl α-L-arabinofuranoside Structure
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Biological Activity

4-Methylumbelliferyl α-L-arabinofuranoside is the glycosidase substrate.

Chemical Information
Molecular Weight 308.28
Formula C15H16O7
CAS Number 77471-44-4
Form Solid
Storage Powder -20°C 3 years
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] B Shafit-Zagardo et al. Biochim Biophys Acta. Electrophoretic separation of neutral and acid beta-glucosidase isozymes in human tissues

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