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4-Methylsalicylic acid

Cat. No. M20499
4-Methylsalicylic acid Structure
Synonym:

m-Cresotic acid, 2-Hydroxy-4-methylbenzoic acid, m-Cresotinic acid, 2-Hydroxy-p-toluic acid

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Biological Activity

4-Methylsalicylic acid is used to inhibit the medium chain acyl-CoA synthetase.

Chemical Information
Molecular Weight 152.15
Formula C8H8O3
CAS Number 50-85-1
Solubility (25°C) DMSO 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Amara Mumtaz, et al. Bioorg Chem. Bisthioureas of pimelic acid and 4-methylsalicylic acid derivatives as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP) and intestinal alkaline phosphatase (IAP): Synthesis and molecular docking studies

[2] Zhi-Ming Zhang, et al. Bioorg Med Chem. Synthesis, biological evaluation and molecular docking studies of 1,3,4-oxadiazole derivatives as potential immunosuppressive agents

[3] A Vonaparti, et al. Anal Bioanal Chem. Direct injection horse urine analysis for the quantification and identification of threshold substances for doping control. III. Determination of salicylic acid by liquid chromatography/quadrupole time-of-flight mass spectrometry

[4] F Kasuya, et al. Biochem Pharmacol. Inhibition of a medium chain acyl-CoA synthetase involved in glycine conjugation by carboxylic acids

[5] R G Ankenbauer, et al. Proc Natl Acad Sci U S A. Mutasynthesis of siderophore analogues by Pseudomonas aeruginosa

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Keywords: 4-Methylsalicylic acid, m-Cresotic acid, 2-Hydroxy-4-methylbenzoic acid, m-Cresotinic acid, 2-Hydroxy-p-toluic acid supplier, inhibitors, activators

 
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