Gamma-Guanidinobutyric acid (4-GBA) is used to study intestinal transport by the human proton-coupled amino acid transporter(s) (hPAT1).
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Solubility||Water 22 mg/mL|
|Related Endogenous Metabolite Products|
Eicosapentaenoic acid (EPA) is an omega-3 fatty acid found in fish oil. It acts as a precursor to prostaglandin-3 and thromboxane-3 families. EPA decreases serum lipid concentration, reduces the risk of cardiovascular disorders and suppresses platelet aggregation.Nutritional supplement in health care products.
|Phosphoribosyl pyrophosphate pentasodium
Phosphoribosyl pyrophosphate (PRPP) pentasodium is an important metabolite required for the biosynthesis of purine and pyrimidine nucleotides, the amino acids histidine and tryptophan, and the cofactors NAD and NADP.
Indole-3-pyruvic acid, a ketone analogue of tryptophan, is an orally active AHR agonist. indole-3-pyruvic acid has antioxidant properties and can be used in studies of inflammation, anxiety.
Methyl Β-D-galactopyranoside (Methyl β-D-Galactopyranoside ) is an endogenous metabolite. Inside cells, methyl-Β-D-galactopyranoside is mainly located in the cytoplasm. Outside the human body, methyl-Β-D-galactopyranoside can be found in cereals and cereal products.
N-Acetyl-L-glutamic acid is an N-acyl-L-amino acid that is a component of animal cell culture media. It is the first intermediate involved in arginine biosynthesis in prokaryotes and simple eukaryotes, and is a regulator of the urea cycle.
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