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4-Guanidinobutanoic acid

Cat. No. M10155
4-Guanidinobutanoic acid Structure
Synonym:

Gamma-Guanidinobutyric acid; 4-GBA

Size Price Availability Quantity
100mg USD 77  USD77 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Gamma-Guanidinobutyric acid (4-GBA) is used to study intestinal transport by the human proton-coupled amino acid transporter(s) (hPAT1).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 145.16
Formula C5H11N3O2
CAS Number 463-00-3
Purity >98%
Solubility Water 22 mg/mL
Storage at -20°C
References

[1] Zhipan Zhang, et al. J Phys Chem B. Influence of 4-guanidinobutyric acid as coadsorbent in reducing recombination in dye-sensitized solar cells

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Keywords: 4-Guanidinobutanoic acid, Gamma-Guanidinobutyric acid; 4-GBA supplier, Endogenous Metabolite, inhibitors

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