4-Deoxypyridoxine hydrochloride is a vitamin B6 antimetabolite with several biological activities. It inhibits the transport and reduces the growth of pyridoxine, pyridoxal and pyridoxamine in S. carlsbergensis cells. 4-DPD inhibits sphingosine-1-phosphate (S1P) lyase and reduces apoptosis of alveolar epithelial MLE-12 cells induced by cyclic stretch.
| Molecular Weight | 189.64 |
| Formula | C8H12ClNO2 |
| CAS Number | 148-51-6 |
| Solubility (25°C) | DMSO: 10 mg/ml |
| Storage | RT |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[5] S P Coburn, et al. J Biol Chem. In vivo metabolism of 4'-deoxypyridoxine in rat and man
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