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4,4'-DDE

Cat. No. M20488
4,4'-DDE Structure
Synonym:

p,p'-DDE; Dichlorodiphenyldichloroethylene; p,p'-dichlorodiphenyldichloroethylene

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Quality Control & Documentation
Biological Activity

DDE, a breakdown product of DDT, is an organochlorine pesticide and may behave as a potent androgen receptor antagonist.

Chemical Information
Molecular Weight 318.03
Formula C14H8Cl4
CAS Number 72-55-9
Solubility (25°C) DMSO 63 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ximena Fadic, et al. Sci Total Environ. Tradescantia as a biomonitor for pesticide genotoxicity evaluation of iprodione, carbaryl, dimethoate and 4,4'-DDE

[2] Muhittin Onur Aka, et al. Bull Environ Contam Toxicol. 4,4'-DDE and Endosulfan Levels in Agricultural Soils of the Çukurova Region, Mediterranean Turkey

[3] Kady Lyons, et al. Mar Environ Res. Effects of trophic ecology and habitat use on maternal transfer of contaminants in four species of young of the year lamniform sharks

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Keywords: 4,4'-DDE, p,p'-DDE; Dichlorodiphenyldichloroethylene; p,p'-dichlorodiphenyldichloroethylene supplier, Estrogen Receptor, inhibitors, activators


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