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(3S,4S)-A2-32-01 is the less active (S,S)-enantiomer of A2-32-01.A2-32-01 is a potent inhibitor of caseinolytic protease protease (ClpP).
| Molecular Weight | 301.42 |
| Formula | C19H27NO2 |
| Form | Oil |
| Solubility (25°C) | DMSO 100 mg/mL |
| Storage | -20°C, protect from light |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related ClpP Products |
|---|
| Z-GGF-CMK
Z-GGF-CMK is a protease inhibitor, inhibits ClpP1P2 and proteasome. |
| (3R,4R)-A2-32-01
(3R,4R)-A2-32-01 is the (R,R)-enantiomer of A2-32-01 and an inhibitor of Staphylococcus aureus caseinolytic protease (SaClpP). |
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