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3-Nitropropionic acid is a irreversible mitochondrial respiratory complex II (succinate dehydrogenase) inhibitor; induces autophagy in SH-SY5Y cells. Recapitulates Huntington's disease-like pathology and symptoms in primate and rodent models.
| Molecular Weight | 119.08 |
| Formula | C3H5NO4 |
| CAS Number | 504-88-1 |
| Form | Solid |
| Solubility (25°C) | DMSO 11.91 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Thomas Birkelund, et al. Fatal 3-Nitropropionic Acid Poisoning after Consuming Coconut Water
[5] C V Borlongan, et al. 3-Nitropropionic acid animal model and Huntington's disease
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